[Note: one wipe = one alarm, e.g. '1 wipe diaper' approximates a 1 alarm fire]
1 wipe diaper: slight mess, but compact; damage control and clean-up can be accomplished in two swipes of the same wet wipe
2 wipe diaper: one wipe for damage control, one wipe for final spot-checking and cleaning; each wipe may be used more than once by creative folding and positioning.
3 wipe diaper: starting to get directional flows; messier. Use the diaper itself to swipe the bulk of the mess to the seat of the diaper before proceeding to wipes. One wipe to assist the diaper's aim, one for major remaining mess on buttocks and genital area, & the third wipe for final clean-up.
4 wipe diaper: Now you need to be careful - the mess will start to migrate if you don't take precautionary steps. For example, either take off all clothing or push it above the baby's nipple line. Do yourself a favor and remove socks ahead of time. Wipe downward with the diaper before using wet wipes. One wipe for mess around the rear-end crease, one for final clean-up there - rest baby's bottom on the new, clean diaper and continue. Wipe #3 for major clean-up around genitals & wipe #4 for final clean-up.
5 wipe diaper: Here and beyond can easily become a disaster. Mess migrates via clothing to stomach, chest, back, legs, hands. Again, start at the back and work front - Wipes 1 & 2, rear-end damage control & clean-up; wipes 3 & 4, genital damage control & clean-up; wipe 5 should be used for peripheral damage or to assist any of the other tasks.
Put the kid on the floor with a burp pad under his head before washing your hands thoroughly with soap. Don't give him the opportunity to roll off the changing table and add to the day's battles!